Anna Clarendon Cox (1828-1870) married Richard Ramsbottom Isherwood in 1844 and their children were:
James Clarendon (1845-1913) married Mary Jane McCormack
Charles Edward (1849-1934) married Isabel Catherine Bonsor
Francis William (1851-1888)
Frederick Augustus (1853-1892)
Laura Constance (1857-1941) married Robert Rentoul
Annie Cecile (1862-1906) unmarried